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Principal Investigator

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Kyle A. Cottrell

Purdue University

Assistant Professor of Biochemistry

RNA editing, post-transcriptional regulation, cancer

Lab Manager

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Holly Bohlin

Purdue University

Lab Manager and Research Technician

cancer, bioinformatics, RNA therapeutics

Graduate Students

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Addison Young

Purdue University

Graduate Student

Protein Structure-Function Relationships, Cancer Development

Undergraduate Researchers

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David Onishile

Purdue University

Undergraduate Researcher

Cancer cell culture, immunology, gene editing

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Estelle Gardner

Purdue University

Undergraduate Researcher

Human disease and therapeutics

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Madison Liu

Purdue University

Undergraduate Researcher

cancer, therapeutics, protein engineering

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Renee Chua

Purdue University

Undergraduate Researcher

Cancer, immunotherapy, drug discovery

Alumni

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Jackson Pierce

Research Technician

ALS-related proteinopathy, cancer, genetics

Philosophy

We recognize that the pursuit of scientific knowledge is not an equitable endeavor. Systematic biases often influence who can pursue academic research. To that end, it is the goal of this laboratory to do our part to make that pursuit equitable. We will do so by making the laboratory an inclusive and diverse workplace by following the below tenets:

  1. Sexism, racism, classism, or other forms of discrimination have no place in the laboratory.

  2. Every member of the lab has a voice, and their voice should be heard.

  3. Inclusivity and diversity will make our team stronger.

  4. Everyone in the laboratory is entitled to appropriate training, resources, and mentorship.

We will make every effort to ensure that our work is robust, reproducible, and accessible.

Publications

(2024). Suppression of double-stranded RNA sensing in cancer; molecular mechanisms and therapeutic potential. Biochemical Society Transactions.

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(2024). Activation of PKR by a short-hairpin RNA. Scientific Reports.

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(2024). Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells. Cancer Research Communications.

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(2024). The competitive landscape of the dsRNA world. Molecular Cell.

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(2021). 8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR. Cancer Research Communications.

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(2021). Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer. Oncogene.

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(2020). Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor. Scientific Reports.

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(2019). A short translational ramp determines the efficiency of protein synthesis. Nature Communications.

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(2018). PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs. Nature Communications.

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(2017). Translation efficiency is a determinant of the magnitude of miRNA-mediated repression. Scientific Reports.

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(2011). Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena. BMC Cell Biology.

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