RNA binding proteins in cancer

RNA binding proteins (RBPs) play numerous roles in regulating mRNAs: splicing, localization, translation, degradation, modification, etc. Because these processes are integral to the post-transcriptional regulation of all mRNAs, RBPs are critical components of cellular physiology. Due to their wide ranging effects, many RBPs have been implicated in oncogenesis or tumor supression. One project in the Cottrell Lab focuses on the RBP ADAR, which edits RNA and supresses dsRNAs sensing. This function of ADAR is essential in many cancer cell lines, making ADAR an attractive therapeutic target. The goal of this project is to uncover other RBPs that may serve as therapeutic targets for cancer treatment.

More details to come…